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What is considered the first sign of anaphylactic shock?

  1. Swelling of the throat

  2. Difficulty in breathing

  3. Itching and redness of the skin

  4. Nausea and vomiting

The correct answer is: Itching and redness of the skin

The first sign of anaphylactic shock is commonly recognized as itching and redness of the skin. This initial response is often due to the release of histamines and other inflammatory mediators from mast cells and basophils as the body reacts to an allergen. Itching, also known as pruritus, serves as a warning signal that the body is experiencing an allergic reaction, which can rapidly advance to more severe symptoms. While swelling of the throat, difficulty in breathing, and gastrointestinal symptoms like nausea and vomiting can occur as the allergic reaction progresses, they usually manifest after the initial cutaneous symptoms. Recognizing these early signs is crucial for prompt intervention, as the condition can escalate quickly, making early detection and treatment vital in preventing more serious complications such as airway obstruction or cardiovascular collapse.